Office: LU Jia-xi Building 528　
Tel: 2180278　
Email: jhgao@xmu.edu.cn
Address: State Key Laboratory of Physical Chemistry of Solid Surfaces

Education:
B.S., Chemistry, Nanjing University, China　( 2000 - 2004 )
Ph.D., Chemistry, HKUST, Hong Kong, China　( 2004-2008 )

Principal Research Interests:
Our research interests are focused on the design of biofunctional nanomaterials and their applications in biology and medicine, such as biosensors, cell biology, drug delivery, molecular imaging, and cancer therapy.

Selected Recent Publications:

1. 1. Zheng, L.; Peng, Q.; Sun, H.; Deng, J.; Jiang, Y.; Xiong, Y.; Chen, L.; Cui, X.; Lin, H.*; Chen, Z.*; Wang, X.*; Gao, J. H.* SABRE Hyperpolarized Multichannel ¹⁹F NMR for Sensitive Detection of Multiple Disease Marker Enzymes on a Benchtop NMR. Angew. Chem. Int. Ed. 2026, 65, e17348.

2. 2. Jiang, Y.; Fan, Y.; Chen, L.; Lin, H.*; Gao, J. H.* Super-Multiplexed Imaging and Coding in the Range of Radio Frequency. Nat. Commun. 2025, 16, 2567.

3. 3. Jiang, Y.; Chen, L.; Wang, J.; Lin, H.*; Gao, J. H.* Small Fluorinated Aromatic Molecule-Based Radiofrequency Identification Tags Enabled by Stepwise Tuning of Nuclear Shielding. Angew. Chem. Int. Edit. 2025, 64, e202506846.

4. 4. Chen, D.; Lin, Y.; Fan, Y.; Li, L.; Tan, C.; Wang, J.; Lin, H.*; Gao, J. H.* Glycan Metabolic Fluorine Labeling for In Vivo Visualization of Tumor Cells and In Situ Assessment of Glycosylation Variations. Angew. Chem. Int. Edit. 2023, 62, e202313753.

5. 5. Chen, D.; Guo, J.; Li, A.; Sun, C.; Lin, H.; Lin, H.*; Yang, C.*; Wang, W.*; Gao, J. H.* Metabolic Fluorine Labeling and Hotspot Imaging of Dynamic Gut Microbiota in Mice. Science Advances 2023, 9, eabg6808.

6. 6. Luo, X.; Gong, X.; Su, L.; Lin, H.; Yang, Z.; Yan, X.; Gao, J. H.* Activatable Mitochondria-Targeting Organoarsenic Prodrugs for Bioenergetic Cancer Therapy. Angew. Chem. Int. Ed. 2021, 60, 1403-1410.

7. 7. Lin, H. Y.; Tang, X.; Li, A.; Gao, J. H.* Activatable ¹⁹F MRI Nanoprobes for Visualization of Biological Targets in Living Subjects. Adv. Mater. 2021, 33, 2005657.

8. 8. Zhu, X. L.; Tang, X.; Lin, H. Y.; Shi, S.; Xiong, H.; Zhou, Q.; Li, A.; Wang, Q.; Chen, X.; Gao, J. H.* A Fluorinated Ionic Liquid-Based Activatable ¹⁹F MRI Platform Detects Biological Targets. Chem 2020, 6, 1134-1148.

9. 9. Sun, C. J.; Lin, H. Y.; Gong, X. Q.; Yang, Z.; Mo, Y.; Chen, X.; Gao, J. H.* DOTA-Branched Organic Frameworks as Giant and Potent Metal Chelators. J. Am. Chem. Soc. 2020, 142, 198-206.

10. 10. Zhang, Y. J.*; Zhang, L.; Gao, J. H.*; Wen, L. P.* Pro-Death or Pro-Survival: Contrasting Paradigms on Nanomaterial-Induced Autophagy and Exploitations for Cancer Therapy. Acc. Chem. Res. 2019, 52, 3164-3176.